Source: National Cancer Institute Research, www.cancer.gov
Screening is looking for cancer before a person has any symptoms. This can help find cancer at an early stage. When abnormaltissue or cancer is found early, it may be easier to treat. By the time symptoms appear, cancer may have begun to spread.
Scientists are trying to better understand which people are more likely to get certain types of cancer. They also study the things we do and the things around us to see if they cause cancer. This information helps doctors recommend who should be screened for cancer, which screening tests should be used, and how often the tests should be done.
It is important to remember that your doctor does not necessarily think you have cancer if he or she suggests a screening test. Screening tests are given when you have no cancer symptoms.
If a screening test result is abnormal, you may need to have more tests done to find out if you have cancer. These are called diagnostic tests.
The ovaries are a pair
of organs in the female reproductive
system. They are located in the pelvis, one on each side of the
uterus (the hollow, pear-shaped
organ where a fetus grows). Each
ovary is about the size and shape of an almond. The ovaries produce eggs and
female hormones (chemicals that
control the way certain cells or
See the following PDQ summaries for more information about ovarian cancer:
Ovarian cancer is also the leading cause of death from cancer of the female reproductive system. Since 1992, the number of new cases of ovarian cancer has gone down slightly. The number of deaths from ovarian cancer has slightly decreased since 2002.
Anything that increases your chance of getting a disease is called a risk factor. Anything that decreases your chance of getting a disease is called a protective factor
For information about risk factors and protective factors for ovarian cancer, see the Ovarian Cancer Prevention summary.
Some screening tests are used because they have been shown to be helpful both in finding cancers early and in decreasing the chance of dying from these cancers. Other tests are used because they have been shown to find cancer in some people; however, it has not been proven in clinical trials that use of these tests will decrease the risk of dying from cancer.
Scientists study screening tests to find those with the fewest risks and most benefits. Cancer screening trials also are meant to show whether early detection (finding cancer before it causes symptoms) decreases a person's chance of dying from the disease. For some types of cancer, finding and treating the disease at an early stage may result in a better chance of recovery.
Screening for ovarian cancer has not been proven to decrease the death rate from the disease.
Screening for ovarian cancer is under study and there are screening clinical trials taking place in many parts of the country. Information about ongoing clinical trials is available from the NCI Web site.
A pelvic exam is an exam of the vagina, cervix, uterus, fallopian tubes, ovaries, and rectum. The doctor or nurse inserts one or two lubricated, gloved fingers of one hand into the vagina and the other hand is placed over the lower abdomen to feel the size, shape, and position of the uterus and ovaries. A speculum is also inserted into the vagina and the doctor or nurse looks at the vagina and cervix for signs of disease.
Ovarian cancer is usually advanced when first found by a pelvic exam.
Transvaginal ultrasound (TVU) is a procedure used to examine the vagina, uterus, fallopian tubes, and bladder. An ultrasound transducer (probe) is inserted into the vagina and used to bounce high-energy sound waves (ultrasound) off internal tissues or organs and make echoes. The echoes form a picture of body tissues called a sonogram.
A CA 125assay is a test that measures the level of CA 125 in the blood. CA 125 is a substance released by cells into the bloodstream. An increased CA-125 level is sometimes a sign of certain types of cancer, including ovarian cancer, or other conditions.
Scientists at the National Cancer Institute studied the combination of using TVU and CA-125 levels as a way to screen for and prevent deaths from ovarian cancer. The results of this study showed no decrease in deaths from ovarian cancer.
Decisions about screening tests can be difficult. Not all screening tests are helpful and most have risks. Before having any screening test, you may want to talk about the test with your doctor. It is important to know the risks of the test and whether it has been proven to reduce the risk of dying from cancer.
Screening may not improve your health or help you live longer if you have advancedovarian cancer or if it has already spread to other places in your body.
Some cancers never cause symptoms or become life-threatening, but if found by a screening test, the cancer may be treated. It is not known if treatment of these cancers would help you live longer than if no treatment were given, and treatments for cancer may have serious side effects.
Screening test results may appear to be normal even though ovarian cancer is present. A woman who receives a false-negative test result (one that shows there is no cancer when there really is) may delay seeking medical care even if she has symptoms.
Screening test results may appear to be abnormal even though no cancer is present. A false-positive test result (one that shows there is cancer when there really isn't) can cause anxiety and is usually followed by more tests (such as a laparoscopy or a laparotomy to see if cancer is present), which also have risks. Complications from tests to diagnose ovarian cancer include infection, blood loss, bowel injury, and heart and blood vessel problems. An unnecessary oophorectomy (removal of one or both ovaries) may also result.
Your doctor can advise you about your risk for ovarian cancer and your need for screening tests.