Major depression is one of the most common mental disorders in the United States. Treatment-resistant depression is a very common clinical problem that is likely to affect more than one-third of depressed patients. At any given time, that can be more than 3 million US citizens.
Depression often strikes during a person’s prime years. It is estimated to impact 12% of all men, and 20% of women at some point during their lives. The World Health Organization currently ranks depression as one of the most disabling diseases in the world. Untreated depression can have many devastating consequences such as: Difficulty in the workplace, absenteeism, relationship problems as well as marital and family discord.